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Engineering and Technology

BMCE Faculty Candidate: Bio-inspired Drug Delivery Systems for Cancer Immunotherapy

January 10, 2020 at 9:30am10:30am

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Quanyin Hu, Ph.D., from the Massachusetts Institute of Technology, is a candidate for a faculty position in the Department of Biomedical and Chemical Engineering, part of the cluster hiring initiative in the BioInspired Institute.

Abstract: Cancer immunotherapy has attracted great attention in recent years. Drug delivery system has enabled a wide array of improvements in cancer immunotherapy, ranging from increased cancer vaccination to enhanced delivery of immune checkpoint inhibitors. Armed with a better understanding of biological activities and physiological signals, the treatment paradigm can be shifted to great outcomes by integrating materials chemistry, pharmaceutical science, and biomolecular engineering together to precisely deliver cancer immunotherapeutics in a spatial and temporal manner. In this seminar, I will introduce my ongoing efforts in the design of bio-inspired drug delivery systems capable of mimicking biological particulates or responding to physiological environments for enhanced cancer immunotherapy. I will first present the hematopoietic stem cells (HSCs) and platelets assembly for enhanced delivery of immune checkpoint inhibitors to the bone marrow for effective leukemia recurrence treatment. I will further introduce the Chimeric Antigen Receptor (CAR)-T cells and platelets cell combination delivery for treatment of solid tumor. Finally, I will describe the efforts on application of a microparticle platform to optimize the therapeutic window of various treatment regimens for improved cancer immunotherapy.

This event was first published on January 6, 2020 and last updated on January 10, 2020.


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