BioInspired Seminar: How Vimentin Regulates Cell Signaling and Controls Matrix Remodeling

The Mechanics of Disease and Development focus group presents:

Professor Christopher McCulloch and Dr. Zofia Ostrowska, University of Toronto

“How vimentin Regulates Cell Signaling and Controls Matrix Remodeling”

The expression of the intermediate filament protein, vimentin, is a widely recognized marker of fibroblasts and of epithelial-mesenchymal transition. But it is not understood how vimentin affects signaling that contributes to cell migration and the remodeling of the extracellular matrix. We will consider how specific properties of vimentin, and its ability to bind critical proteins that control cell attachment to the underlying matrix, and regulate mesenchymal cell migration and remodeling of the matrix by resident fibroblasts.

To register to attend by Zoom, please use this link.